Leeper Group at the University of Akron


My group studies the structures of protein-protein, protein-nucleic acid, protein-metal ion, and peptide-metal ion complexes. Predominantly we use Nuclear Magnetic Resonance spectroscopy (NMR), but also routinely employ X-ray crystallographic, proteomic, biochemical, cytological, and molecular biology techniques. Ultimately we wish use our analysis of complex formation and structure to understand how inter-molecular complexes function in cell biology and disease. A number of specific topics are currently under investigation:

NMR methods for ortholog specific fragment-based drug discovery.

Proteins that bind to long non-coding RNA and generate epigenetic change.

Silver(I) metallated protein structure.

Novel peptide chelators for silver(I).

Prospective students and post-docs interested in joining my research group should contact me directly: tleeper@uakron.edu


Macromolecular complexes: structure and function

UA chemistry
UA chemistry
Departmental Instrumentationhttp://www.uakron.edu/chemistry/facilities.dot
Resources and linkshttp://www.uakron.edu/chemistry/chemlinks.dot
Forms and admissionshttp://www.uakron.edu/chemistry/chemlinks.dot