Leeper Group at the University of Akron

 
 

My group studies the structures of protein-protein, protein-nucleic acid, protein-metal ion, and peptide-metal ion complexes. Predominantly we use Nuclear Magnetic Resonance spectroscopy (NMR), but also routinely employ X-ray crystallographic, proteomic, biochemical, cytological, and molecular biology techniques. Ultimately we wish use our analysis of complex formation and structure to understand how inter-molecular complexes function in cell biology and disease. A number of specific topics are currently under investigation:


NMR methods for ortholog specific fragment-based drug discovery.


Proteins that bind to long non-coding RNA and generate epigenetic change.


Silver(I) metallated protein structure.


Novel peptide chelators for silver(I).


Prospective students and post-docs interested in joining my research group should contact me directly: tleeper@uakron.edu




 

Macromolecular complexes: structure and function

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