Christin's Prepping for Comprehensive Exams
-ddw's comments in red text
I have a different problem, I think, than the other class members...I am developing my research methodology, not for my thesis, but for my comprehensive exam (which I am taking in June)...
My firm and serious advice is to go to your advisor and ask them how to prepare for this exam, both quesions, but specifically about the methodology question.
Basically, I have been told to research 3 topics, examine the literature for the last five years and be prepared to answer 2 questions, one of which involves research methodology and designing a "future study" where there appears to be a need as indicated by the literature...
Well, there it is, then.
The topic I am doing for the "research" question is zinc deficiency in Prader-Willi Syndrome...basically, the suggestion for future research is as simple as suggesting that serum levels of zinc get tested in this population.
I read your statement above that you had to be prepared to discuss 3 topics - only one is listed here Prader-Willi
If that is true -that you only need to design a future study on one topic. Then in your last five years research on p-w, you should make a point of summarizing the literature on the syndrome.   I doubt that testing blood serum zinc levels is going to cut it. Maybe too simple.

The research I find quickly on a google scholar search talks about zinc-finger encoding, which I gather is a chromasome kind of thing.
needless to say, this kind of stuff is out of my experience ....
Here, we provide a detailed investigation of a mouse model deficient for Necdin. Linked to the mutation, a neonatal lethality of variable penetrance is observed. Viable Necdin mutants show a reduction in both oxytocin-producing and luteinizing hormone-releasing hormone (LHRH)-producing neurons in hypothalamus.  These researchers are using laboratory animals for study.

Basically you'd try to design your study based on previous work in the field.
Collect your literature review notes and include research questions, hypotheses, and methodologies used.
If you are intending to replicate or extend this research tradition, you'd have to understand what others have done.